Detailed view for TVAG_238650

Basic information

TDR Targets ID: 921218
Trichomonas vaginalis, calmodulin, putative
Source Database / ID: 

pI: 4.3865 | Length (AA): 160 | MW (Da): 18416 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128884)

Species Accession Gene Product
Arabidopsis thaliana AT3G50360   centrin2
Babesia bovis BBOV_III003480   EF hand domain containing protein
Cryptosporidium hominis Chro.30159   centrin
Cryptosporidium parvum cgd3_1270   centrin, putative
Drosophila melanogaster Dmel_CG17493   CG17493 gene product from transcript CG17493-RB
Echinococcus granulosus EgrG_000843000   centrin 2
Echinococcus granulosus EgrG_000964800   Centrin 1
Echinococcus granulosus EgrG_000968500   centrin 2
Echinococcus multilocularis EmuJ_000964800   Centrin 1
Echinococcus multilocularis EmuJ_000968500   centrin 2
Echinococcus multilocularis EmuJ_000843000   centrin 2
Giardia lamblia GL50803_6744   Centrin
Homo sapiens 1069   centrin, EF-hand protein, 2
Homo sapiens 1068   centrin, EF-hand protein, 1
Leishmania braziliensis LbrM.07.0780   centrin, putative,caltractin, putative
Leishmania donovani LdBPK_070790.1   centrin, putative
Leishmania infantum LinJ.07.0790   centrin, putative,caltractin, putative
Leishmania major LmjF.07.0710   centrin, putative,caltractin, putative
Leishmania mexicana LmxM.07.0710   centrin, putative,caltractin, putative
Mus musculus ENSMUSG00000031347   centrin 2
Mus musculus 26369   centrin 1
Neospora caninum NCLIV_063750   Calmodulin, related
Oryza sativa 4343922   Os07g0618800
Plasmodium berghei PBANKA_0206300   centrin-1, putative
Plasmodium falciparum PF3D7_0107000   centrin-1
Plasmodium knowlesi PKNH_0206500   centrin-1, putative
Plasmodium vivax PVX_081420   centrin-1, putative
Schistosoma japonicum Sjp_0011490   Centrin-1, putative
Schistosoma mansoni Smp_134950   centrin-related
Schmidtea mediterranea mk4.004035.00   Uncharacterized calcium-binding protein
Schmidtea mediterranea mk4.003529.04  
Schmidtea mediterranea mk4.000308.09  
Schmidtea mediterranea mk4.000114.07  
Schmidtea mediterranea mk4.001420.01  
Trypanosoma brucei gambiense Tbg972.8.645   centrin, putative,caltractin, putative
Trypanosoma brucei Tb927.8.1080   centrin, putative
Trypanosoma congolense TcIL3000_8_680   centrin, putative
Trypanosoma cruzi TcCLB.503727.10   centrin, putative
Trypanosoma cruzi TcCLB.506401.90   centrin, putative
Toxoplasma gondii TGME49_247230   centrin
Theileria parva TP03_0058   centrin, putative
Trichomonas vaginalis TVAG_238650   calmodulin, putative
Trichomonas vaginalis TVAG_311320   calmodulin, putative
Trichomonas vaginalis TVAG_311330   caltractin, putative

Essentiality

TVAG_238650 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.1080 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.1080 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.1080 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.1080 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0206300 Plasmodium berghei Essential plasmo
TGME49_247230 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Calmodulin 149 aa 53.8% 143 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_238650 (Trichomonas vaginalis), calmodulin, putative
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